NovoArc’s Tetraether lipids
NovoArc produces lipids derived from an extremophilic archaeon, an organism capable of thriving under extreme environmental conditions such as low pH and high temperatures. Due to the ether linkages of their saturated phytane chains, which are resistant to hydrolytic and enzymatic cleavage, these organisms have evolved highly robust cell walls in order to survive in such environments. Additionally, the saturated nature of the carbon backbone provides exceptional resistance to oxidation. Compared to conventional natural or synthetic lipids, which contain ester bonds and varying degrees of unsaturation, tetraether lipids offer superior oxidative, hydrolytic (pH 1.0–10.0), thermal (above 140°C), and enzymatic stability. These properties allow tetraether lipids to endure the harsh conditions of the gastrointestinal tract (including pH, enzymes, and bile salts), making them an attractive alternative for the delivery of various APIs.
A semi-synthetic production process
NovoArc has developed a patented biotechnological process for the continuous production of tetraether lipids. We hold extensive know-how for the chemical modification of lipids to tailor these substances for certain pharmaceutical applications and cargos. The process is well-defined, controllable, reproducible, and scalable, and it was developed in alignment with Quality by Design (QbD) principles.
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